upend

1. (transitive) To end up; to set on end.

2. (transitive, figurative) To destroy, invalidate, overthrow, or defeat.Examples: "The scientific evidence upended the popular myth."; "James Meredith's forced admission was a milestone in upending the old order in America's most segregated state, a kind of race relations ground zero."; "What is unbearable, in fact, is the feeling, 13 years after 9/11, that America has been chasing its tail; that, in some whack-a-mole horror show, the quashing of a jihadi enclave here only spurs the sprouting of another there; that the ideology of Al Qaeda is still reverberating through a blocked Arab world whose Sunni-Shia balance (insofar as that went) was upended by the American invasion of Iraq."

3. (transitive, figurative) To affect or upset drastically.Examples: "By the middle of March 2020, the COVID-19 pandemic upended normal life for virtually all Americans."; "Coral, another company trying to upend the salon industry, obtained $4.3 million in venture funding around the same time. But Bradley Leong, the company’s chief executive and co-founder, said that because they could not get the device’s price as low as they had hoped in its current iteration, they were making it semirobotic to decrease the cost."; "A week of public health reversals from the White House and the Centers for Disease Control and Prevention has left Americans with pandemic whiplash, sowing confusion about coronavirus vaccines and mask-wearing as the Delta variant upends what people thought they knew about how to stay safe."