noun

• (countable) A cause of misery or ruin.
  "the bane of one’s existence"
• (countable, archaic) Chiefly in the names of poisonous plants or substances: a poison.
  "For my part I would rather counſell you to deſtroy your Rattes and Miſe with Traps, Banes, or Weeſels: for beſides the ſluttiſhneſſe & lothſomeneſſe of the Catte (you know what ſhe layes in the Malt heape) ſhe is moſt daungerous and pernicious among children, as I mee ſelf haue had good experience."
• (uncountable, chiefly poetic) Misery, woe; also, doom, ruin; or physical injury, harm.
  "Hath ſome fond lover tic'd [i.e., enticed] thee to thy bane? / And vvilt thou leave the Church, and love a ſtie?"
• (uncountable, UK, dialectal, veterinary medicine) A disease of sheep in which breakdown of tissue occurs; rot.

verb

• (archaic)
  "Think when thou ſéeſt the baite whereon is thy delite, / That hidden Hookes are hard at hande to bane thee when thou bite."
• (archaic)
  "It [covetousness] annoyeth our Phiſitions, it infecteth our Diuines, it choaketh our Lawiers, it woundeth our Farmers, it baneth our Gentlemen, it murdereth our Tradeſmen, it bewitcheth our Merchants, it ſtingeth our Marriners. Oh couetouſneſſe, couetouſneſſe: it is the poyſon of all things, the wound of Chriſtianitie, the bane of all goodneſſe."
• (UK, dialectal, veterinary medicine) To cause (sheep) a disease, especially the rot (“a disease in which breakdown of tissue occurs”).
• (obsolete) To kill (a person or animal), especially by poison.
  "Aconit is of two ſortes (as Dioſcorides writeth) the one is named Aconitum Pardalianches, that is to ſay, Aconite that baneth, or killeth Panthers."

noun

• (chiefly Scotland) Alternative spelling of bone.
  "If meate or drinke thou never gavest nane, / Every night and alle: / The fire will burn thee to the bare bane; / And Christe receive thye saule."