adj

• (informal) (Very) drunk or intoxicated.
  "Dear old Squiffy was always rather a lad for the wassail-bowl. When I met him in Paris, I remember, he was quite tolerably blotto."

noun

• (informal) A person who is (very) drunk or intoxicated.
  "Remember, Blanche DuBois was a blotto and her trip to New Orleans didn't get her anywhere. Nuff said."
• (art) An artwork created using blots of ink or paint.
  "The authors' most penetrating work seems to me, their contribution along the lines of the interview with the child, the use of sketches, blottoes, etc. "Draw a picture of this house. Who lives there? Show where the different members sleep" […]"

verb

• (intransitive, informal) To become or cause to become (very) drunk or intoxicated.
  "An entire bottle would have blottoed me. I marvel how Leigh managed to give my name to the manager."
• (intransitive, informal) To be annihilated or destroyed; to be blotted out.
  "[H]is soul, spinning in centrifugal lust and fury until he sputters out through the hole in the center of him; going down like a gas bag—vault, cellar, ribs, skin, blood, tissue, mind, and heart all consumed, devoured, blottoed in final annihilation."

noun

• (biochemistry) A reagent made from non-fat dry milk, phosphate buffered saline, and sodium azide, which is used to block protein binding sites for laboratory techniques such as blots and the enzyme-linked immunosorbent assay (ELISA).
  "Secondary goat anti-rabbit antiserum coupled to horseradish peroxidase at a dilution of 1:500 in blotto was then incubated with the blot for 1 hour. Again the unbound antibodies were removed by three rinses in 10% blotto for 15 minutes."