noun

• (medicine) An abnormal condition of a human, animal or plant that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired.
  "The tomato plants had some kind of disease that left their leaves splotchy and fruit withered."
• (figuratively) Any abnormal or harmful condition, as of society, people's attitudes, way of living etc.
  "War is not man's great and terrible disease; war is a symptom, a result. The real disease is the virus of national sovereignty."

verb

• (obsolete) To cause unease; to annoy, irritate.
  "Whyll he yett ſpeake there cam won from the rulers off the ſynagogis houſſe which ſayde to hym: Thy doughter is deed diſeaſe not the maſter."