noun

• (by extension) Something that destroys or negates, especially on a catastrophic scale.
• (nautical) A vessel such as a ship or submarine running on nuclear power.
  "A nuke [nuclear submarine] can't survive with one flooded compartment. Any compartment that floods is going to kill you. Okay? Now, that's an acceptable risk because the nuclear hull is made of better steel. If a surface ship hits a nuclear submarine, the surface ship is going to sink, which we've demonstrated again and again. [...] In a nuke you come to periscope depth once a day, every two days."
• (warez) A cautionary flag placed on a release to label it as "bad" for some reason or another (e.g., being a dupe of a previous release or containing malware).
  "A nuke based on non existent rules or made up reasons can be undone – this is called and^([sic]) un-nuke."
• (rare) A microwave oven.
  "Just put it in the nuke for two minutes and it will be ready to eat."

verb

• (transitive, chiefly US, colloquial) To use a nuclear weapon on (a target).
  "If a nuclear war ever breaks out, military facilities are likely to be nuked first."
• (transitive, chiefly US, colloquial, figuratively) To destroy or erase completely.
  "He had his posts nuked from the Google archives."
• (transitive, Internet slang, by extension) To carry out a denial-of-service attack against (an IRC user).
  "The command and control servers used by the Mydoom variant, responsible for the recent denial of service attacks against Korean and US government websites, receive instructions from a master server located in the UK. [...] Apparently, the decision of whoever was responsible to damage the infected systems after July 10 pointed [Roger] Thompson in this direction. "Why bother nuking 60k computers after doing all the work of assembling them? Nuking them only helps the Good Guys, because the victims are forced to re-build, and therefore clean, their computers. [..."]"
• (transitive, chiefly US, colloquial) To expose to some form of radiation.

noun

• (anatomy, obsolete) Alternative form of nucha (“spinal cord; nape of the neck”).
  "The organ of amativeness is placed in the nuke of the neck as a protuberance of the cerebellum."

noun

• (chiefly Northern England, archaic) Alternative form of nook (“a corner of a piece of land; an angled piece of land, especially one extending into other land”).
  "The ancient bounds of the cow paſture of Penrith, [...] and then from the ſaid Old Dyke end, alongſt Plumpton Dyke Eaſt over Petterel unto Plumpton park nuke, otherwiſe called Plumpton nuke; [...]"